| 摘要: |
| 雷公藤红素为卫矛科植物雷公藤的主要活性成分之一，是一种醌甲基三萜类化合物，外观呈红色针状结晶体，具有多种生物学活性。2015年，雷公藤红素被发现具有显著减肥的作用，从而引起了大量学者的关注。近年来，越来越多的研究表明其在抗肿瘤方面具有较明显的药理活性，可通过多种信号通路抑制乳腺癌、前列腺癌、肺癌、结直肠癌、胃癌、肝癌等。本文就近年来雷公藤红素的抗肿瘤作用及其作用机制展开综述，旨在为雷公藤红素的深入研究提供新的思路。 |
| 关键词: 雷公藤红素 抗肿瘤 药理活性 研究进展 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.10.020 |
| 分类号:R284.1 |
| 基金项目:国家自然科学基金项目（81360665，81760747）；广西自然科学基金项目（2015GXNSFAA139114，2013GXNSFBA019174）；广西卫生厅中医药攻关课题（GZGG13-08） |
|
| Progress in Anti-tumor Effect of Celastrol |
|
JIA Lulu, TAN Qinyou
|
|
Guilin Medical University, Guilin 541001, China
|
| Abstract: |
| Celastrol is one of the main active ingredients of Tripterygium wilfordii. It is a quinone-methyl triterpene compound with red needle-like crystal appearance and has a lot of biological activities. In 2015, celastrol is found to have a super-slimming effect, which attract a lot of scholars' interest. In recent years, more and more studies have shown that it has obvious pharmacological activity in anti-tumor. It can inhibit breast cancer, prostate cancer, lung cancer, colorectal cancer, stomach cancer, liver cancer and the like through various signaling pathways. In this review, the anti-tumor effect of celastrol and its mechanism are described in order to provide new ideas for its further study. |
| Key words: celastrol anti-tumor pharmacological activity progress |
