1例阿帕替尼在晚期非小细胞肺癌老年患者的临床药学监护

Pharmacist-managed Apatinib Treatment of One Elderly Patient with Advanced NSCLC

关键词:  阿帕替尼  老年患者  非小细胞肺癌  高血压  蛋白尿  手足反应

Key words:  apatinib  elderly patient  NSCLC  hypertension  proteinuria  HFSR

摘要:

目的 探讨新型抗肿瘤药物阿帕替尼在晚期非小细胞肺癌（non-small cell lung cancer，NSCLC）老年患者中的治疗与药学监护。方法 通过药学查房、医师-药师双师门诊等方式，临床药师参与1例阿帕替尼在晚期NSCLC中的治疗，结合药物特性及患者伴有高血压、老年等特殊情况，提出用药建议、指导患者用药，积极处理药物相关不良反应及对未出现的不良反应提出预防监护措施。结果 经过实施个体化药学监护，患者咳嗽咳痰等临床症状明显好转，肺部CT显示肿瘤病灶明显减小且患者生存质量较好，患者得到有效治疗。结论 临床药师深入临床实践，对患者药物治疗过程进行药学监护，能更好地发挥自身的价值，尤其在参与新药临床治疗中更为重要。

Abstract:

OBJECTIVE To explore the treatment and pharmaceutical care of apatinib in elderly patients with advanced non-small cell lung cancer(NSCLC). METHODS Clinical pharmacists participated in the treatment of a case of apatinib in advanced NSCLC by means of pharmaceutical rounds and doctor-pharmacist outpatient service. Combined with the characteristics of drugs and the special conditions of patients with hypertension and old age, put forward suggestions for drug use, guided patients to use drugs, actively dealt with drug-related adverse reactions and put forward preventive and monitoring measures for the non-existent adverse reactions. RESULTS Through the individualized pharmaceutical care of the patients, the patients' clinical symptoms such as cough and expectoration were significantly improved. Lung CT showed that the tumor focus was significantly reduced and the patients' quality of life was good, and the patients were effectively treated. CONCLUSION Clinical pharmacists go deep into clinical practice, take part in the pharmaceutical care of patients in the process of drug treatment which can better play their own value especially for the treatment experience of new drugs.