临床药师对乳腺癌合并甲状腺功能减退患者的药学监护

Pharmaceutical Care of Clinical Pharmacist for the Patient with Breast Cancer Complicated with Hypothyroidism

关键词:  曲妥珠单抗  乳腺癌  甲状腺功能减退症  药物相互作用  药学监护

Key words:  trastuzumab  breast cancer  hypothyroidism  interactions of drugs  pharmaceutical care

摘要:

目的 探讨临床药师对乳腺癌靶向治疗合并甲状腺功能减退患者药学监护的意义。方法 临床药师对1例合并甲状腺功能减退症的乳腺癌患者进行全程用药监护，重点分析单抗类抗肿瘤药物和甲状腺功能减退症治疗药物使用情况。结果 曲妥珠单抗与甲状腺功能减退症用药互有影响，造成用药风险的增加及药物疗效的降低，临床药师对其进行用药监护，通过合理调整左旋甲状腺素剂量及用法，提高了患者生存质量，实现个体化监护。结论 对于存在甲状腺功能减退的乳腺癌患者，临床药师需重点实施药学服务，评估疾病及药物相互作用影响，从而促进合理用药。

Abstract:

OBJECTIVE To explore the significance of clinical pharmacist in the pharmaceutical care of breast cancer patients with targeted therapy complicated with hypothyroidism. METHODS A breast cancer patient complicated with hypothyroidism was monitored for whole course medication by clinical pharmacist, and the use of mono antibody anti-tumor drugs and hypothyroidism drugs were analyzed. RESULTS Trastuzumab had an effect on the use of hypothyroidism drugs, resulting in an increased risk of medication and a reduction in the drug efficacy. Clinical pharmacists monitored the use of drugs. By reasonably adjusting the dose and usage of levothyroxine, the life quality of patient was improved and individual monitoring was realized. CONCLUSION For breast cancer patients with hypothyroidism, clinical pharmacists need to focus on the implementation of pharmaceutical services and assess the impact of disease and drug interactions to promote rational drug use.