七氟醚在脑中风疾病中的神经保护作用研究进展

Research Progress on Neuroprotective Effect of Sevoflurane Against Cerebral Ischemic Stroke

关键词:  七氟醚  脑缺血  预处理  后处理  神经保护

Key words:  sevoflurane  cerebral ischemia  preconditioning  postconditioning  neuroprotection

摘要:

脑中风是一种以脑部缺血和出血性损伤为主要临床表现的疾病。它是全球性死亡的主要原因之一，可以引起患者严重的长期残疾和认知功能障碍。然而，目前可用在脑中风患者身上的有效保护措施非常有限，尤其是针对那些围手术期患者。近年来，包括七氟醚在内的多种吸入麻醉剂的介入为脑缺血中风患者的神经保护开辟了一条新道路。在大脑缺血损伤中，七氟醚可以通过抗氧化、抗凋亡、抑制炎症反应、调节大脑血流量、维持血脑屏障和促进神经再生等来发挥神经保护作用。此文对七氟醚在脑缺血-再灌注损伤中的临床应用及神经保护作用相关机制进行综述，旨在阐明七氟醚在脑中风的神经保护中的重要作用。

Abstract:

Stroke is a disease characterized by brain ischemia and hemorrhagic injury. It is one of the leading causes of global death and can cause severe long-term disability and cognitive dysfunction in patients. However, the effective protective measures currently available for patients with stroke are very limited, especially for perioperative patients. In recent years, the involvement of various inhaled anesthetics, including sevoflurane, has opened a new path for neuroprotection in patients with cerebral ischemic stroke. In cerebral ischemic injury, sevoflurane can play a neuroprotective role, such as anti-oxidation, anti-inflammatory, anti-apoptosis, regulation of cerebral blood flow and substance metabolism, maintenance of blood-brain barrier and neural remodeling. This article reviews the clinical application and neuroprotective mechanisms of sevoflurane in cerebral ischemia-reperfusion injury, which aims to elucidate the important role of sevoflurane in the neuroprotection of stroke.