补肾调冲方在多囊卵巢综合征中的辅助治疗作用及机制研究

Research on Adjunctive Therapeutic Effects and Mechanism of Bushen Tiaochong Decoction in Polycystic Ovary Syndrome

关键词:  补肾调冲方  促排卵法  多囊卵巢综合征  氧化应激  临床疗效

Key words:  Bushen Tiaochong Decoction  ovulation induction  polycystic ovary syndrome  oxidative stress  clinical efficacy

摘要:

目的 探讨补肾调冲方辅助促排卵法治疗多囊卵巢综合征（polycystic ovary syndrome，PCOS）的临床疗效及作用机制。方法 选取新乡医学院第一附属医院2016年1月—2018年12月符合PCOS诊断标准的病例100例，进行临床随机对照研究，以随机数表法分为观察组和对照组，每组50例。对照组采取炔雌醇环丙孕酮片+来曲唑进行治疗，观察组在对照组治疗方案的基础上给予补肾调冲方治疗，总疗程为6个月经周期，记录2组患者临床资料，检测治疗前后患者脂肪细胞因子、性激素、氧化应激等指标。结果 治疗后，观察组内脂素、瘦素、睾酮、促黄体生成激素（luteotropic hormone，LH）、卵泡刺激素（follicle-stimulating，FSH）、LH/FSH、丙二醛水平以及流产率显著低于对照组（P<0.05）；脂联素、雌二醇、超氧化物歧化酶、谷胱甘肽过氧化物酶水平，排卵率及妊娠率水平显著高于对照组（P<0.05）。结论 补肾调冲方对PCOS有较好的辅助治疗作用，可有效调节性激素水平，改善氧化应激状态，缓解胰岛素抵抗。

Abstract:

OBJECTIVE To investigate clinical efficacy and mechanism of Bushen Tiaochong Decoction adjuvant ovulation induction in treating polycystic ovary syndrome(PCOS). METHODS One hundred PCOS cases conforming diagnostic criteria in the First Affiliated Hospital of Xinxiang Medical University were selected by clinical randomized controlled trial from January 2016 to December 2018. They were divided into observation group and control group by random number table, 50 cases in each group. Patients in the control group was treated with ethinylestradiol cyproterone combined with letrozole, while patients in the observation group were given the treatment of Bushen Tiaochong Decoction on the basis of the treatment of the control group. The total course of treatment was 6 menstrual cycles. Then the clinical data of the two groups were recorded, and fat cytokines, sex hormones, oxidative stress and other indicators were measured before and after treatment. RESULTS After treatment, the visfatin, leptin, testosterone, luteotropic hormone(LH), follicle-stimulating(FSH), LH/FSH, malondialdehyde levels and abortion rate the in observation group were significantly lower than those of the control group (P<0.05); adiponectin levels, estradiol levels, superoxide dismutase, glutathione peroxidase levels, ovulation rate and pregnancy rate were significantly higher than those of the control group(P<0.05). CONCLUSION Bushen Tiaochong Decoction has a good adjuvant therapeutic effect on PCOS, which can regulate the level of sex hormones effectively, improve oxidative stress and alleviate insulin resistance.