| 引用本文: | 沈秀芸,吕保江,武敏,林宇轩,蒋雅楠,白云龙.三氧化二砷联合用药治疗乳腺癌的研究进展[J].中国现代应用药学,2020,37(11):1392-1396. |
| SHEN Xiuyun,LYU Baojiang,WU Min,LIN Yuxuan,JIANG Yanan,BAI Yunlong.Research Progress of Arsenic Trioxide-related Combined Therapy in the Treatment of Breast Cancer[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(11):1392-1396. |
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| 三氧化二砷联合用药治疗乳腺癌的研究进展 |
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沈秀芸1, 吕保江1, 武敏1, 林宇轩1, 蒋雅楠1,2, 白云龙1,2
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1.哈尔滨医科大学药学院药理学教研室, 哈尔滨 150081;2.黑龙江省医学科学院北方转化医学研究合作中心, 哈尔滨 150081
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| 摘要: |
| 乳腺癌是女性发病率最高的恶性肿瘤之一。药物治疗和放射疗法是乳腺癌临床治疗的主要手段，但仍存在不良反应大，肿瘤易耐药等问题。三氧化二砷是治疗急性早幼粒细胞白血病的一线用药，其也可联合多种药物对乳腺癌等实体瘤产生良好疗效，并在一定程度上缓解临床治疗弊端。本文综述三氧化二砷联合化疗药、激素类药、营养补充剂、中药等多种药物或放射疗法对乳腺癌的研究进展，为乳腺癌联合用药研究提供新思路。 |
| 关键词: 三氧化二砷 乳腺癌 联合用药 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.11.021 |
| 分类号:R979.1 |
| 基金项目:国家自然科学基金项目（81803524，81673426）；黑龙江省高等教育教学改革项目（SJGY20180318）；黑龙江省自然科学基金项目（LH2019H003）；中国博士后科学基金项目（2018M641878）；黑龙江省博士后资助经费项目（LBH-Z18168） |
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| Research Progress of Arsenic Trioxide-related Combined Therapy in the Treatment of Breast Cancer |
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SHEN Xiuyun1, LYU Baojiang1, WU Min1, LIN Yuxuan1, JIANG Yanan1,2, BAI Yunlong1,2
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1.Department of Pharmacology, School of Pharmacy, Harbin Medical University, Harbin 150081, China;2.North Cooperative Center for Translational Medical Research, Heilongjiang Academy of Medical Sciences, Harbin 150081, China
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| Abstract: |
| Breast cancer is one of the most common forms of malignancy in women. Drug therapy and radiation therapy are commonly used in the clinical treatment of breast cancer. However, there are still problems of these therapeutic strategies, such as side effects and drug resistance. Arsenic trioxide is a first-line therapeutic drug for acute promyelocytic leukemia. Combined with other drugs, it also exerts an excellent curative effect on many solid tumors such as breast cancer and reduces the disadvantages of clinical treatment. This article reviews the research progress of arsenic trioxide combined therapy with chemotherapy drugs, hormonal drugs, nutritional supplements, traditional Chinese medicine, etc., as well as radiation therapy on breast cancer, in order to provide new ideas for drug combination research on breast cancer treatment. |
| Key words: arsenic trioxide breast cancer combined medication |
