基于德尔菲法构建碳青霉烯类抗菌药物合理应用敏感指标

Establishment of Sensitive Indexes System of Rational Application of Carbapenem Antibiotics Constructed Based on Delphi Method

关键词:  敏感指标  碳青霉烯  德尔菲专家函询法  合理用药

Key words:  sensitive indexes  carbapenem  Delphi method  rational application

摘要:

目的 构建碳青霉烯类抗菌药物合理应用敏感指标。方法 通过国内外文献检索和研究小组讨论，初步确立碳青霉烯类抗菌药物合理应用敏感性指标，并采用德尔菲专家函询法，对药学、医学及微生物检验人员各18名进行2轮函询，统计整理函询结果。结果 构建的碳青霉烯类抗菌药物合理应用敏感指标包括一级指标3项，二级指标11项和三级指标26项。2轮专家函询有效回收率分别为86.4%和94.7%，权威系数分别为0.83和0.88。第1轮总体协调系数0.169，第2轮总体协调系数0.304。3项一级指标的协调系数分别为0.414，0.308和0.311，经χ²检验后均有统计学意义（P<0.01）。结论 构建的碳青霉烯类抗菌药物合理应用敏感指标具有一定可信度，可为碳青霉烯类抗菌药物合理应用的管理与评价提供客观、可量化的评估工具。

Abstract:

OBJECTIVE To establish sensitive indexes for the rational application of carbapenems antibiotics. METHODS The sensitivity index of rational application of carbapenems antibiotics was preliminarily established by searching literatures and discussion of the research group, the Delphi method was adopted to conduct 2 rounds of letter consultation for 18 pharmaceutical, medical and microbiological inspectors respectively, and the results were statistically sorted out. RESULTS The sensitive indexes of rational application of carbapenem antibiotics constructed included 3 first-level indexes, 11 second-level indexes and 26 third-level indexes. The positive coefficients in the two rounds of expert consultation were respectively 86.4% and 94.7%, and the authoritative coefficients were 0.83 and 0.88. Kendall's W of the first rounds was 0.169, and the second rounds was 0.304. The 3 first-level indexes were 0.414, 0.308 and 0.311, respectively, there were statistically significant by χ² test (P<0.01). CONCLUSION The sensitive quality indicators based on modified Delphi technique in the rational application of carbapenems antibiotics are credibility. It can provide an objective and quantifiable evaluation tool for the quality evaluation of the rational application of carbapenems antibiotics in pharmaceutical management.