白花蛇舌草抗炎、抗肿瘤作用研究进展

Research Progress of Anti-inflammatory and Anti-tumor Effects of Hedyotis Diffusa Willd.

关键词:  炎-癌转化  白花蛇舌草  抗炎  抗肿瘤

Key words:  inflammation-cancer transformation  Hedyotis diffusa Willd.  anti-inflammatory  anti-tumor

摘要:

慢性炎症与肿瘤的发生、发展、侵袭、转移等密切相关，清热解毒中药白花蛇舌草兼具抗炎、抗肿瘤作用，在临床上常用于各种炎症、肿瘤的预防与治疗。白花蛇舌草抗炎机制研究主要涉及NF-kB、MAPK、5-LOX等信号通路，抗肿瘤研究主要为抗肠癌、抗肺癌、抗肝癌、抗乳腺癌、抗胃癌等，机制涉及PI3K/AKT、TGF-β/Smad、MAPK、STAT3等信号通路，并可能通过NF-kB、MAPK、VEGF等途径在“炎-癌”转化过程中发挥重要作用。本文综述白花蛇舌草抗炎、抗肿瘤及干预“炎-癌”转化作用，为其进一步研究提供参考。

Abstract:

Chronic inflammation is closely related to the occurrence, development, invasion and metastasis of tumors. Hedyotis diffusa Willd. has both anti-inflammatory and anti-tumor effects and is often used to prevent and treat various kinds of inflammation and tumors. The anti-inflammatory mechanism of Hedyotis diffusa Willd. is related to NF-κB, MAPK, 5-LOX and other signaling pathways and the anti-tumor effects include anti-colon cancer, anti-lung cancer, anti-liver cancer, anti-breast cancer, anti-gastric cancer, etc and anti-tumor mechanisms include signaling pathways such as PI3K/AKT, TGF-/Smad, MAPK, STAT3. Hedyotis diffusa Willd. plays an important role in the process of "inflammation-cancer" transformation through NF-κB, MAPK, VEGF and so on. This study provides a reference for the further research and development of the anti-inflammatory, anti-tumor properties and intervention on "inflammation-cancer" transformation of Hedyotis diffusa Willd.