肠缺血再灌注损伤的分子机制及中药干预研究进展

Progress of the Molecular Mechanisms and Traditional Chinese Medicines Intervention on Intestinal Ischemia-Reperfusion Injury

关键词:  肠缺血再灌注损伤  天然产物  分子机制  预防  治疗

Key words:  intestinal ischemia-reperfusion  natural products  molecular mechanism  prevention  treatment

摘要:

肠缺血再灌注（intestinal ischemia-reperfusion，II/R）损伤是一种常见的临床疾病，发病率呈逐年上升趋势。II/R除了造成肠黏膜屏障局部损伤加重胃肠道自身损伤外，还由于内毒素吸收增加和肠道细菌移位使网状内皮系统释放大量促炎介质，引发全身炎症反应综合征，导致远隔脏器损伤和多器官功能障碍综合征的发生。因此，研究II/R损伤的发病机制并寻求有效的预防和治疗方法具有重要意义。本文从氧化应激、炎症、细胞凋亡、自噬和miRNAs等方面对II/R损伤的发生发展机制，以及近年来中药预防和治疗II/R损伤的研究进展进行综述，为临床诊治II/R损伤提供信息和参考。

Abstract:

Intestinal ischemia-reperfusion (II/R) injury is a common clinical disease with the increasing incidences year by year. II/R can not only cause local damage and increase gastrointestinal injury of intestinal mucosa, but also can cause reticuloendo-thelial system to release a large amount of proinflammatory factors because of endotoxin absorption and intestinal bacterial translocation, which can then cause systemic inflammatory response syndrome and eventually led to multiple organ dysfunction syndrome and distant organ injury. Therefore, it is of great significance to study the pathogenesis of II/R injury and to find effective prevention and treatment methods. In this paper, the items of reactive oxygen species, inflammation, apoptosis, autophagy, and microRNAs were reviewed on the mechanisms of II/R injury, as well as the progress of traditional Chinese medicines on prevention and treatment of the disease in recent years, which will provide information and reference for clinical diagnosis of II/R injury.