| 引用本文: | 李君,祖文,刘静,王跃武,武世奎.ZnO@ZnFe2O4乳膏的制备工艺及皮肤用药安全性评价[J].中国现代应用药学,2020,37(23):2828-2833. |
| LI Jun,ZU Wen,LIU Jing,WANG Yuewu,WU Shikui.Preparation Progress of ZnO@ZnFe2O4 Cream and Its Safety Evaluation of Skin Medication[J].Chin J Mod Appl Pharm(中国现代应用药学),2020,37(23):2828-2833. |
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| ZnO@ZnFe2O4乳膏的制备工艺及皮肤用药安全性评价 |
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李君1,2, 祖文3, 刘静1,2, 王跃武1,2, 武世奎3
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1.内蒙古医科大学, 新药安全评价研究中心, 呼和浩特 010110;2.内蒙古医科大学, 新药筛选工程研究中心, 呼和浩特 010110;3.内蒙古医科大学, 药学院, 呼和浩特 010110
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| 摘要: |
| 目的 研究ZnO@ZnFe2O4乳膏的制备工艺及皮肤用药的安全性。方法 采用正交试验方法优选ZnO@ZnFe2O4乳膏的成型工艺；采用Buehler试验，观察豚鼠皮肤接触ZnO@ZnFe2O4乳膏后的过敏情况；将ZnO@ZnFe2O4乳膏单次或多次涂于新西兰兔完整及破损皮肤处，观察药物对皮肤的刺激情况；新西兰兔皮肤单次给药观察药物的急性毒性。结果 ZnO@ZnFe2O4乳膏的最佳工艺条件：乳化剂的用量为6%，乳化时间为20 min，搅拌速度为1 600 r·min-1，乳化温度为80℃；采用最佳工艺制备的ZnO@ZnFe2O4乳膏对豚鼠皮肤未产生致敏反应，对兔皮肤未产生刺激性，对兔皮肤未引起急性毒性反应。结论 ZnO@ZnFe2O4乳膏经皮给药安全可靠。 |
| 关键词: ZnO@ZnFe2O4乳膏 皮肤刺激性 皮肤致敏性 |
| DOI：10.13748/j.cnki.issn1007-7693.2020.23.002 |
| 分类号:R943 |
| 基金项目:国家自然科学基金项目（81503351，81760750）；内蒙古医科大学青年创新基金项目（YKD2017QNCX028，YKD2018QNCX023） |
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| Preparation Progress of ZnO@ZnFe2O4 Cream and Its Safety Evaluation of Skin Medication |
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LI Jun1,2, ZU Wen3, LIU Jing1,2, WANG Yuewu1,2, WU Shikui3
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1.The Center of New Drug Safety Evaluation and Research, Inner Mongolia Medical University, Hohhot 010110, China;2.Engineering Research Center of New Pharmaceutical Screening, Inner Mongolia Medical University, Hohhot 010110, China;3.School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China
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| Abstract: |
| OBJECTIVE To study the preparation progress and safety of skin medication of ZnO@ZnFe2O4 cream. METHODS Optimizing molding technology of ZnO@ZnFe2O4 cream was optimized by orthogonal experiment method. Buehler test was performed for evaluating the degree of allergy in guinea pig after skin contact with ZnO@ZnFe2O4 cream. Skin irritation was monitored by applying ZnO@ZnFe2O4 cream on the intact and wounded skin of rabbits in single or multiple times. Single administration was given to observe the acute toxicity of ZnO@ZnFe2O4 on New Zealand rabbits. RESULTS The optimized condition was shown below: emulsifier dosage was 6%, emulsifying time was 20 min, stirring speed was 1 600 r·min-1, emulsifying temperature was 80 ℃. The optimized progress producted-ZnO@ZnFe2O4 cream wasn't caused allergy in guinea pig, also wasn't caused side effects and acute toxicity in rabbits' skin. CONCLUSION Transdermal administration is a safety way for ZnO@ZnFe2O4 cream. |
| Key words: ZnO@ZnFe2O4 cream skin sensitization skin irritation |
