即时检验在治疗药物监测中的应用研究进展

Advances in the Application of Point-of-care Testing in Therapeutic Drug Monitoring

关键词:  治疗药物监测  即时检验  免疫层析  微流控  表面等离子体共振  化学发光  生物传感器

Key words:  therapeutic drug monitoring  point-of-care testing  immunochromatography  microfluidic  surface plasmon resonance  chemiluminescence  biosensor

摘要:

治疗药物监测是指在一定时间段内对患者的体液进行药物浓度测定，以及时控制药物的剂量，对药物毒性以及不良反应进行及时干预并调整药物剂量以达到更好的疗效。即时检验（point-of-care testing，POCT）可用于治疗药物监测，它能够快速、灵敏、方便地检测患者体内药物浓度，方便临床指导个体化用药，减少药物的不良反应。近年来国外一些研究者对多种POCT方法在治疗药物监测领域的应用进行了研究，但国内这方面的研究比较少见，为了解更多POCT方法在药物浓度测定的应用，本文从治疗药物监测方面综述该方法的应用研究进展。

Abstract:

Therapeutic drug monitoring is used to measure the concentration of pharmaceutical drug in patients' bio-fluids at certain time intervals to allow a timely control of their dosage. This practice allows for rapid medical intervention in case of toxicity-related issues and adjustment of dosage to better fit the therapeutic demand. Point-of-care testing(POCT) can be used in therapeutic drug monitoring to measure the concentration of drug simply rapidly and sensitively. It is convenient for personalized drug therapy for clinical guidance and reduce adverse reactions of drugs. Some POCT assays has been developed and studied for therapeutic drug monitoring in recent years by foreign researchers, but few in domestic. In order to get more information about the application of POCT in therapeutic drug monitoring, for understanding more application of drug concentration determination, the application of this method is reviewed from the aspect of therapeutic drug monitoring in this article.