异鼠李素抗动脉粥样硬化作用的研究进展

Advances in the Research on the Anti-atherosclerosis Effects of Isorhamnetin

关键词:  异鼠李素  动脉粥样硬化  氧化型低密度脂蛋白  巨噬细胞

Key words:  isorhamnetin  atherosclerosis  oxygenated-low density lipoprotein  macrophage

摘要:

近年来，由动脉粥样硬化（atherosclerosis，AS）引发的心脑血管疾病已成为导致全球人类死亡的重要原因之一。据相关研究表明，AS的发生主要与高血压、高血脂、肥胖及吸烟等因素息息相关。氧化型低密度脂蛋白（oxygenated-low density lipoprotein，ox-LDL）作为AS发展过程中一个极其危险的因素，可通过诱导机体出现一系列的病理生理改变而促进AS的形成。大量研究发现，沙棘中的主要生物活性物质沙棘总黄酮的重要单体成分——异鼠李素（isorhamnetin，ISO）具有抗氧化、保护内皮细胞、抑制内皮细胞与单核细胞黏附、降低脂质沉积、抑制血管平滑肌细胞增殖与迁移及抗血栓等多种心血管保护作用，进而可在防治AS方面发挥重要作用。本研究以AS发生机制为基础，就ISO抗AS病理生理过程中的药理作用作以综述。

Abstract:

In recent years, cardiovascular and cerebrovascular diseases caused by atherosclerosis(AS) have become one of the main causes of human death in the worldwide. According to relevant studies, hypertension, high blood fat, obesity, smoking and other factors are closely related to the occurrence of AS. As an extremely dangerous factor in the development of AS, oxygenated low density lipoprotein(ox-LDL) can promote the formation of AS by inducing a series of pathophysiological changes in the body. A large number of studies have found that isorhamnetin(ISO), an important monomer of sea buckthorn flavonoids, have much cardiovascular protective effects, such as anti-oxidation, protection of endothelial cell barriers, inhibition of adhesion between endothelial cells and monocytes, reduction of lipid deposition, inhibition of proliferation and migration of vascular smooth muscle cell, and anti-thrombosis. Then, ISO could play a significant role in the prevention and treatment of AS. Based on the occurrence mechanism of AS, this paper summarizes the anti-atherosclerosis effects of ISO in the pathophysiology process of AS.