基于群体药动学模型的奥卡西平个体化给药软件研制

Development of Software for Individualizing Dosage Regimens of Oxcarbazepine Based on Population Pharmacokinetics Models

关键词:  奥卡西平  10,11-二氢-10-羟基卡马西平  群体药动学  个体化给药  给药软件

Key words:  oxcarbazepine  monohydroxycarbazepine  population pharmacokinetics  dose individualization  dosing software

摘要:

目的 研制基于群体药动学（population pharmacokinetics，PPK）模型的奥卡西平（oxcarbazepine，OXC）个体化给药软件。方法 根据已建立的成人和儿童OXC活性代谢物10，11-二氢-10-羟基卡马西平（monohydroxycarbazepine，MHD）的PPK模型信息，运用MyEclipse、SQL Server、JRE等工具研制OXC给药软件。软件开发方案包括软件需求分析、软件概要设计、软件详细设计、软件编码、软件测试以及软件维护和二次开发。结果 研制的OXC给药软件可实现患者信息输入和管理，能自动调用NONMEM软件，能预测多种具体给药方案下的MHD血药浓度，供临床制定初始给药方案参考，而且能结合已有的血药浓度监测信息和Bayesian反馈法更精准地预测血药浓度，辅助临床进一步优化给药方案。结论 基于MHD的PPK模型研制的给药软件能快捷方便地辅助成人和儿童癫痫患者OXC的个体化给药。

Abstract:

OBJECTIVE To develop a software for individualizing dosage regimens of oxcarbazepine(OXC) based on the population pharmacokinetics(PPK) models. METHODS OXC dosing software was developed by MyEclipse, SQL Server, JRE and so on, according to the monohydroxycarbazepine(MHD)'s PPK model of adults and children. The software developing schemes included requirement analysis, general design, detailed design, software coding, software test, software maintenance and software redevelopment. RESULTS The software was able to input and manage patient information, run NONMEM automatically, predict blood concentrations under various dosing regimens which could help initial dosage design, and predict blood concentrations more accurately based on therapeutic drug monitoring results and Bayesian method in dosage adjustment. CONCLUSION This new developed software based on MHD's PPK models can give assistance to facilitate the individualized therapy for epilepsy patients expediently.