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| 摘要: |
| 利用硼鳌合物的方法,增大6—氟与7—氯取代活性的差异,使哌嗪化选择性取代收率达到82.3%。 |
| 关键词: 诺氟沙星 合成 硼鳌合物 |
| DOI： |
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| Improvement of technological process for Synthesis of Norfloxacin |
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Ji Genghao
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| Abstract: |
| Norfloxacin was prepared according to the Boric coordination complex method with mod ification. An available process starting from ethyl-1-ethyl-6-fluoro-7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate to Norfioxacin in 82.3% yield was described. |
| Key words: Norfloxacin synthesis Boric coordination complex |
