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| 摘要: |
| 用a-溴丙酰氯作为起始物经3步反应合成硫普罗宁。通过a-溴丙酰甘氨酸和硫代乙酸反应，然后脱
去乙酰基而引入巯基，研究了脱保护方法。 |
| 关键词: 硫普罗宁 保肝 解毒 合成 |
| DOI： |
| 分类号: |
| 基金项目: |
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| Synthesis of Tiopronin |
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Dai Hua Cheng，Shu Ping，Xiong Zi Ping
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| Abstract: |
| Tiopronin was synthesized by 3 steps with α-bromopropionyl chloride as starting material．Mercapto group was introduced by treating α-bromopropionyl glycine with thioacetic acid and then removing the acetyl group．The process was studied． |
| Key words: Tiopronin Hepatocyte protection Antidote Synthesis |
