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| 关键词: 西布曲明 减肥药 合成 |
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| Synthesis of sibutramine hydrochloride |
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Xu Yungen(Xu YG),Luo Sui(Luo S),Hua Weiyi(Hua WY)
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| Abstract: |
| OBJECTIVE:To modify the synthetic method of sibutramine hydrochloride.METHOD:Sibutramine hydrochloride was synthesized from 4-chlorophenylacetonitrile by reactions of cycloalkylation,Grignard reaction,reduction,Eschweiler Clarke methylation and salifying |
| Key words: sibutramine,anti obesity drug,synthesis |
