| 引用本文: | 吕竹芬;谭载友;张蜀;黄宇辉;邓海燕;洪晓鹏;张燕珊.美沙拉嗪缓释片的处方筛选及体外释放度研究[J].中国现代应用药学,2000,(6):461-463. |
| Lü Zhufen(Lü ZF),Tan Zaiyou(Tan ZY),Zhang Shu(Zhang S),et al.Prepaeration and release of sustained release mesalazine tablets[J].Chin J Mod Appl Pharm(中国现代应用药学),2000,(6):461-463. |
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| 摘要: |
| 目的:制备美沙拉嗪缓释片剂,并评价其体外释放特性。方法:用正交试验设计对片剂的处方进行筛选,制备美沙拉嗪缓释片剂,测定其释放特性。结果:以优选的处方所制备的片剂,体外释药性能符合Higuchi模型,持续释药达8h。结论:该片剂工艺简单,可适合工业化生产 |
| 关键词: 美沙拉嗪 缓释片 处方 正交试验 释放度 |
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| Prepaeration and release of sustained release mesalazine tablets |
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Lü Zhufen(Lü ZF),Tan Zaiyou(Tan ZY),Zhang Shu(Zhang S),et al
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| Abstract: |
| OBJECTIVE:To prepare sustained release tablets and evaluate its drug release property.METHOD:The formulation of the tablet was found by orthogonal design test.RESULTS:The release rate of the prepared tablets conformed to Higuchi equation and the drug was |
| Key words: mesalazine,sustained release tablets,formulation,orthogonal design,release rate |
