| 引用本文: | 王宇1,2;陈平3;陈明2;胡艾希1.咪康唑中间体1-(2,4-二氯苯基)-2-(1-咪唑基)乙醇合成新工艺[J].中国现代应用药学,2004,(4):286-287. |
| WANG Yu 1,2, CHEN Ping 3, CHEN Ming 2, HU Ai-xi 1.Synthesis of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol[J].Chin J Mod Appl Pharm(中国现代应用药学),2004,(4):286-287. |
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| 关键词: 合成 1-(2,4-二氯苯基)-2-(1-咪唑基)乙醇 锍内盐 环氧化反应 咪康唑 |
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| Synthesis of 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)ethanol |
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WANG Yu 1,2, CHEN Ping 3, CHEN Ming 2, HU Ai-xi 1
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| Abstract: |
| OBJECTIVE To synthesize 1-(2,4-dichloropheny1)-2-(1-imidazoly1)ethanol. METHOD 1-(2,4-dichloropheny1)-2-(1-imidazoly1)ethanol, the important intermediate of miconazole, was synthesized by epoxidation of 2,4-dichloropheny1aldehyde with sulphonium ylide a |
| Key words: synthesis 1-(2,4-dichloropheny1)-2-(1-imidazoly1)ethanol sulphonium ylide epoxidation reaction miconazole |
