| 引用本文: | 葛海霞1;王礼琛1;余潜2.7-羟基-3,4-二氢-2(1H)-喹啉酮的合成及两个副产物的分离确证[J].中国现代应用药学,2005,(5):390-392. |
| GE Hai-xia,WANG Li-chen,YU Qian~(1).Synthesis of 7-hydroxy-3,4-dihydro-2(1H)-quinolinone[J].Chin J Mod Appl Pharm(中国现代应用药学),2005,(5):390-392. |
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| 摘要: |
| 目的改进7-羟基-3,4-二氢-2(1H)-喹啉酮的合成方法。方法以间氨基苯甲醚为原料,经N-酰化和分子内傅-克烃化反应合成。结果合成了目标化合物,两步反应的总收率为59%,并且分离出第二步反应的两个副产物,它们的结构经波谱确证。结论改进的合成方法适用于工业化生产。 |
| 关键词: 7-羟基-3,4-二氢-2(1H)-喹啉酮 间氨基苯甲醚 合成 分离鉴定 |
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| Synthesis of 7-hydroxy-3,4-dihydro-2(1H)-quinolinone |
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GE Hai-xia,WANG Li-chen,YU Qian~(1)
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| Abstract: |
| OBJECTIVE The purpose is to improve the preparative method of 7-hydroxy-3,4-dihydro-2(1H)-quinolinone.METHOD It was synthesized from m-anisidine via two-step reaction.RESULT The title compound was obtained with 59% overall yield.Two by-products was isolat |
| Key words: 7-hydroxy-3,4-dihydro-2(1H)-quinolinone m-anisidine synthesis isolation identification |
