| 引用本文: | 熊远珍1,2;吴淑芳2;周南进2.恩他卡朋的合成[J].中国现代应用药学,2005,(6):456. |
| XIONG Yuan-zhen~1,WU Shu-fang~2,ZHOU Nan-jin~2.Synthesis of entacapone[J].Chin J Mod Appl Pharm(中国现代应用药学),2005,(6):456. |
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| 摘要: |
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| 关键词: 恩他卡朋 合成 几何异构 纯化 |
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| Synthesis of entacapone |
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XIONG Yuan-zhen~1,WU Shu-fang~2,ZHOU Nan-jin~2
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| Abstract: |
| OBJECTIVE In order to increase product rate,new way has been taken to prepare and purify entacapone.METHOD 3,4-dihydroxy-5-nitro-benzaldehyde was used to react with N,N-diethylcyanoacetamide,between which taking place knoevengal reaction in base condition |
| Key words: entacapone synthesis gemetric isomer purify |
