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| 摘要: |
| 目的改进氟康唑(fluconzole1)的合成工艺。方法用间二氟苯为起始原料,用4-氨基-1H-1,2,4-三氮唑代替1H-1,2,4-三氮唑,分别采用相转移催化和超声波方法,经三步反应制得氟康唑。结果得氟康唑(1),mp137～141℃,总收率50%。结论符合中国药典2000年版二部的标准,工艺可靠,质量稳定。 |
| 关键词: 氟康唑 相转移 合成 超声波 |
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| Study on the new preparation of fluconazole |
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WANG Jian-xiang
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| Abstract: |
| OBJECTIVE To improve the synthesis technology of fluconazole.METHODS Fluconazole was prepared after three steps reaction with m-difluorobenzenes as starting material and 1H-1,2,4-triazole was replaced by 4-amino-1H-1,2,4-triazole.The phase transfer cataly |
| Key words: fluconazole phase transfer preparation ultrasonic |
