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| 关键词: 培美曲塞 抗肿瘤药物 合成 |
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| Synthesis of pemetrexed |
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DAI Hou-ling~(1),CHEN Yu-bin~(2)
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| Abstract: |
| OBJECTIVE To study the synthesis of pemetrexed.METHODS Pemetrexed was synthesized starting from p-iodobenzoic acid via ten steps,including chlorination,esterification,condensation,cyclization,hydrolysis and saponification. RESULTS The structure of the tar |
| Key words: pemetrexed antineoplastic agents synthesis |
