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| 关键词: 美沙拉嗪 结肠靶向微丸 挤出滚圆 结肠溶包衣 |
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| Studies on preparation and dissolution test in vitro of mesalazine colon specific pellets |
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FANG Yu,CAO De-ying
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| Abstract: |
| OBJECTIVE To prepare pH-dependent colonic-targeting pellets of mesalazine by coating with acrylic recin dissoluting in colon,and evaluate dissolution profiles in vitro.METHODS Mesalazine pellets was prepared by extrusion-spheronisation,the condition of te |
| Key words: mesalazine colonic-specific pellets extrusion-spheronisation coating layer dissoluting in colon |
