| 引用本文: | 范彩霞1,2;梁文权2;陈志喜3;喻泽兰1.人工神经网络预测HPMC缓释片中易溶性药物的释放[J].中国现代应用药学,2007,(1):9-12. |
| FAN Cai-xia1,2,LIANG Wen-quan2,CHEN Zhi-xi3,YU Ze-lan1.An Artificial Neural Network to Predict Water Soluble Drug Release from HPMC Sustained Release Tablet[J].Chin J Mod Appl Pharm(中国现代应用药学),2007,(1):9-12. |
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| 关键词: 人工神经网络 响应面法 水溶性药物 羟丙甲基纤维素 缓释片 线性回归 相似因子 |
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| An Artificial Neural Network to Predict Water Soluble Drug Release from HPMC Sustained Release Tablet |
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FAN Cai-xia1,2,LIANG Wen-quan2,CHEN Zhi-xi3,YU Ze-lan1
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| Abstract: |
| OBJECTIVE To use an artificial neural network(ANN) to predict water soluble drug release from HPMC matrix tablets.METHODS 62 formulations of six water soluble model drugs with different solubility(atlachlor,verapamil,hydrochloric ciprofloxacin,doxofylline |
| Key words: artificial neural network response surface methods water-soluble drug HPMC sustained-release tablets linear regression similar factors |
