| 引用本文: | 陈杭;王选;王强力.丙泊酚生理药代动力学模型种间类推的应用[J].中国现代应用药学,2007,(1):46-49. |
| CHEN Hang,WANG Xuan,WANG Qiang-li.The Inter-Species Extrapolation of Propofol PBPK Model[J].Chin J Mod Appl Pharm(中国现代应用药学),2007,(1):46-49. |
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| 摘要: |
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| 关键词: 异丙酚 药代动力学 生理模型 种间类推 |
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| The Inter-Species Extrapolation of Propofol PBPK Model |
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CHEN Hang,WANG Xuan,WANG Qiang-li
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| Abstract: |
| OBJECTIVE To perform the extrapolation of a simplified propofol PBPK model among sheep,rabbit and man.METHODS A simple extrapolation method was proposed.The parameters of the model were extrapolated from sheep to rabbit and human with this method,and the |
| Key words: propofol pharmacokinetics PBPK model extrapolation |
