| 引用本文: | 王绵a;张力辉a;赵占胜a;邓永贵a;周红a;郝咏梅a;苏胜偶a;崔炜b.2型糖尿病大鼠心肌间质胶原代谢的变化及罗格列酮的干预研究[J].中国现代应用药学,2007,(2):100-103. |
| WANG Miana,ZHANG Li-huia,ZHAO Zhan-shenga,DENG Yong-guia,ZHOU Honga,HAO Yong-meia,SHU Sheng-oua,CUI Weib.The Changes of Collagen Metabolism in Rat Heart with Type 2 Diabetes and Preventive Effect of Rosiglitazone[J].Chin J Mod Appl Pharm(中国现代应用药学),2007,(2):100-103. |
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| 摘要: |
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| 关键词: 糖尿病 心肌间质纤维化 基质金属蛋白酶及其组织抑制物 噻唑烷二酮 |
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| The Changes of Collagen Metabolism in Rat Heart with Type 2 Diabetes and Preventive Effect of Rosiglitazone |
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WANG Miana,ZHANG Li-huia,ZHAO Zhan-shenga,DENG Yong-guia,ZHOU Honga,HAO Yong-meia,SHU Sheng-oua,CUI Weib
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| Abstract: |
| OBJECTIVE To Investigate the changes of collagen accumulation,the MMP-2,MMP-9 and TIMP-1 mRNA expressions in cardiac tissue of the rat with type 2 diabetes at different stages and the role of rosiglitazone.METHODS The experimental type 2 diabetic rats wer |
| Key words: diabetes mellitus cardiac fibrosis MMPs/TIMPs thiazolidinediones |
