LC-MS/MS法测定浸润麻醉豚鼠血浆中罗哌卡因浓度

朱狄峰;吴洪海;吴国兰;楼剑书;何俏军;杨波

引用本文:	朱狄峰;吴洪海;吴国兰;楼剑书;何俏军;杨波.LC-MS/MS法测定浸润麻醉豚鼠血浆中罗哌卡因浓度[J].中国现代应用药学,2008,(3):183-186.
	ZHU Di-feng,WU Hong-hai,WU Guo-lan,LOU Jian-shu,HE Qiao-jun,YANG Bo.Determination of Ropivacaine in Guinea Pig Plasma after Infiltration Anaesthesia by Liquid Chromatography-tandem Mass Spectrometry[J].Chin J Mod Appl Pharm(中国现代应用药学),2008,(3):183-186.

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LC-MS/MS法测定浸润麻醉豚鼠血浆中罗哌卡因浓度
朱狄峰;吴洪海;吴国兰;楼剑书;何俏军;杨波

作者	单位
朱狄峰;吴洪海;吴国兰;楼剑书;何俏军;杨波

摘要:

关键词: 罗哌卡因液相色谱-串联质谱浸润麻醉药动学

DOI：

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Determination of Ropivacaine in Guinea Pig Plasma after Infiltration Anaesthesia by Liquid Chromatography-tandem Mass Spectrometry

ZHU Di-feng,WU Hong-hai,WU Guo-lan,LOU Jian-shu,HE Qiao-jun,YANG Bo

Abstract:

OBJECTIVE To develop a sensitive and selective LC-MS/MS method for the determination of ropivacaine and pharmacokinetics in guinea pig plasma.METHODS After a simple sample preparation procedure by one-step protein precipitation with acetonitrile,the HPLC

Key words: ropivacaine LC-MS/MS infiltration anaesthetic pharmacokinetics