| 引用本文: | 张善堂a;屈建a;杨林海b;唐丽琴a;王宁玲b.大剂量甲氨蝶呤在急性淋巴细胞白血病患儿体内的药动学研究[J].中国现代应用药学,2008,(5):454-458. |
| ZHANG Shan-tang a,QU Jian a,YANG Lin-hai b,TANG Li-qin a,WANG Ning-ling b.Pharmacokinetics of High-Dose Methotrexate Infusion in Children with Acute Lymphoblastic Leukemia[J].Chin J Mod Appl Pharm(中国现代应用药学),2008,(5):454-458. |
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| 摘要: |
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| 关键词: 甲氨蝶呤 急性淋巴细胞白血病 儿童 药动学 高效液相色谱法 |
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| Pharmacokinetics of High-Dose Methotrexate Infusion in Children with Acute Lymphoblastic Leukemia |
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ZHANG Shan-tang a,QU Jian a,YANG Lin-hai b,TANG Li-qin a,WANG Ning-ling b
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| Abstract: |
| OBJECTIVE To evaluate the pharmacokinetics of methotrexate(MTX)in children with acute lymphoblastic leukemia(ALL)treated with high-dosage infusion of MTX and combination with calcium folinate(CF)rescued.METHODS The serum samples were collected at differen |
| Key words: methotrexate acute lymphoblastic leukemia(ALL) children pharmacokinetics HPLC |
