71例头孢曲松钠致过敏性休克的分析

Analysis of 71 Cases with Allergic Shock Induced by Ceftriaxone Sodium

关键词:  头孢曲松钠  药物不良反应  过敏性休克  死亡

Key words:  ceftriaxone sodium  adverse drug reactions  anaphylactic shock  death

摘要:

目的分析头孢曲松钠致过敏性休克的发生特点及相关因素，为临床合理使用头孢曲松钠提供参考。方法对国内近14年来发表的71 例头孢曲松钠致过敏性休克病例进行回顾性分析。结果头孢曲松钠可致过敏性休克，严重的过敏性休克可致患者死亡。结论严格用药指征，用药前详细询问过敏史，特别是患者的基础性疾病；加强药物不良反应监测，促进临床合理用药，严防死亡病例发生。

Abstract:

OBJECTIVE To analyze the characteristics and relative factors of allergic shock induced by ceftriaxone sodium, in order to provide reference for the clinical use of ceftriaxone sodium properly.METHODS The 71 reported cases of allergic shock induced by ceftriaxone sodium in China over 14 years were retrospectively analyzed.RESULTS Ceftriaxone sodium could induce allergic shock, and the severe case could cause death.CONCLUSION We should control the drug indication strictly, check patients′ drug allergy history carefully before prescription, especially patients associated with basic diseases, monitor adverse drug reaction（ADR） afterwards, promote clinical rational drug-usage, and prevent death.