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| 摘要: |
| 对临床常用的抗艾滋病病毒药物（拉米夫定、齐多夫定、奈韦拉平、依非韦仑、司他夫定和克力芝）的理化性质，LC-MS测定生物样本药物浓度方法，药动学参数进行总结归类，以指导临床药物浓度监测和科研发展。 |
| 关键词: 抗病毒药物 艾滋病 液相色谱串联质谱；药动学 |
| DOI： |
| 分类号: |
| 基金项目: |
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| Research Advances of AIDs Medicines Determination by LC-MS |
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ZHANG Lijun，YAO Yamin，SUN Jianjun，LU Hongzhou
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| Abstract: |
| The physical and chemical characters,pharmacokinetics of anti-HIV virus medicines(lamivudine,stavudine,zidovudine,efivirenz,nevirapine and lopinavir/ritonavir)and methods used in determining these five medicines by LC-MS have been reviewed.This work can offer some help to treatment drug monitoring(TDM)and anti-HIV medicine research. |
| Key words: anti-virus medicine AIDs LC-MS pharmacokinetics |
