基于文献计量学的中国药品检验机构研究热点与趋势可视化分析

Visualization Analysis of Hotspots and Trends of Drug Control Institutions in China Based on Bibliometrics

关键词:  药品检验机构  文献计量  可视化分析  研究热点

Key words:  drug control institutions  bibliometrics  visualization analysis  research hotspot

摘要:

目的 探究中国药品检验机构的研究现状，分析研究热点与前沿趋势，为后续研究选题提供思路和参考。方法 以中国知网数据库作为中文文献数据源，Web of Science核心数据库作为英文文献数据源，运用CiteSpace 6.1.R6可视化工具软件，从作者和机构合作、关键词共现、关键词聚类及突现分析等方面对中国药品检验机构研究情况进行可视化分析，绘制相关图谱进行比较研究。结果 共纳入中文文献3 711篇，英文文献2 650篇。中国药品检验机构总体发文量呈上升趋势，马双成为最高产的作者，中国食品药品检定研究院为最高产的研究机构，目前的研究热点包括结合具体药物的含量测定、指纹图谱、鉴别评价、溶出机制、有关物质，以及生物技术、纳米材料和毒理替代技术等。前沿研究趋势主要体现在融合先进分析技术和计量方法的药品质量研究、前沿生物制品的检测技术、抗菌活性物质的持续研究。结论 科研人员和机构应抓住热点和趋势，深化研究与合作，为提升药品检验检测能力，助推药品监管现代化发展提供智力支持。

Abstract:

OBJECTIVE To explore the research status of drug control institutions and to analyze the research hotspots and frontier trends, so as to provide references for further research.METHODS Taking CNKI as the data source of Chinese literature, Web of Science Core Collection as the data source of English literature. Using CiteSpace 6.1.R6 visualization tool software, visualization analysis was conducted to the research status of drug control institutions in China from the aspects of author-institution cooperation, keyword co-occurrence, keyword cluster and burst analysis. Meanwhile, draw the relevant maps to do the compare.RESULTS A total of 3 711 Chinese literatures and 2 650 English literatures were included. The number of literatures issued by Chinese drug control institutions showed a rising trend. Ma Shuangcheng was the most prolific author, and National Institutes for Food and Drug Control was the most prolific research institution. Current research hotspots included content determination, fingerprinting, identification evaluation, dissolution mechanism and related substances combining specific drugs, as well as biotechnology, nanomaterials and toxicological substitution technologies. Frontier research trends mainly included drug quality research integrating advanced analytical technology and measurement methods, detection technology of frontier biological products, and continuous research on antibacterial active substances. CONCLUSION Researchers and institutions should grasp hotspots and trends, work at deepen cooperation and research, and provide intellectual support for improving ability of drug inspection and promoting the modernization of drug supervision.