成体海马神经发生障碍在抑郁症中的研究进展

Research progress of adult hippocampal neurogenetic disorders in depression

关键词:  抑郁症  Wnt通路  Shh通路  Notch通路  BMP通路  成体海马神经发生

Key words:  depression  Wnt pathways  Shh pathways  Notch pathways  BMP pathways  adult hippocampal neurogenesis

摘要:

抑郁症作为一种严重威胁人类健康的精神疾病，具有发病率高、隐匿性强、易复发和难治愈等诸多特点。其潜在生物学机制尚不清楚，但分子和信号通路的异常会导致抑郁症。分子信号通路是一种进化上保守的多方面通路，可以控制不同的细胞进程。故深入研究抑郁症的生物学机制，为其预防和治疗提供潜在靶点，这对抗抑郁药物的研发具有显著的临床意义。海马是人体调节情绪和认知功能的关键脑区，成体海马神经发生障碍被认为与抑郁症的发生密切相关。神经发育信号如Wnt、Shh 、Notch、BMP和Noggin等通路在调节成体海马神经发生的微环境中发挥重要作用。通过查阅相关文献，本文综述了上述通路与成体海马神经发生障碍的相关性在抑郁症中的研究进展，为抗抑郁靶点的发现和药物的研发提供新的思路。

Abstract:

As a serious threat to human health, depression has many characteristics, such as high incidence, hidden, easy to relapse and difficult to cure. The underlying biological mechanism is unknown, but abnormalities in molecular and signaling pathways can lead to depression. Molecular signaling pathway is an evolutionarily conserved multifaceted pathway that can control different cellular processes. Therefore, an in-depth study of the biological mechanism of depression provides potential targets for its prevention and treatment, which has significant clinical significance in the development of anti-depression drugs. The hippocampus is a key brain region in regulating emotion and cognitive function. Neurogenetic disorders of the hippocampus in adults are thought to be closely related to the occurrence of depression. Neurodevelopmental signaling pathways such as Wnt, Shh, Notch, BMP, and Noggin play an important role in regulating the microenvironment of adult hippocampal neurogenesis. By reviewing relevant literature, this paper reviews the research progress of the correlation between the above pathways and adult hippocamphal neurogenesis disorders in depression, providing new ideas for the discovery of anti-depression targets and drug development.