| 引用本文: | 廖荣,王捷,时连根,许宗溥,杨明英.天然多酚治疗急性酒精性肝损伤的研究进展[J].中国现代应用药学,2025,42(5):104-111. |
| liaorong,wangjie,shiliangen,xuzongpu,yangmingying.Research Progress in Treating Acute Alcoholic Liver Injury by Natural Polyphenols[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(5):104-111. |
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| 摘要: |
| 短期内大量且高频服用酒精导致的急性酒精性肝损伤严重危害了患者的生命健康，其发生率近年来也显著攀升。天然多酚是从植物中提取的具有优良的抗炎和抗氧化等功效的活性成分，且其因独特的化学结构而显示出更高的类药性。目前，已发现数十种对急性酒精性肝损伤具有治疗作用的天然多酚，而探究相关作用机制无疑将为其深度开发及新型药物设计提供重要参考。本文首先介绍了急性酒精性肝损伤的发病原因，然后在概述天然多酚结构及功效的基础上，总结讨论了其治疗急性酒精性肝损伤的作用机制，最后对天然多酚的未来研究重点作了展望。 |
| 关键词: 急性酒精性肝损伤 天然多酚 作用机制 |
| DOI：10.13748/j.cnki.issn1007-7693.20232130 |
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| 基金项目:财政部和农业农村部 国家现代农业产业技术体系项目（CARS-18-ZJ0501），江西省技术创新引导类计划项目（20212BDH81028） |
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| Research Progress in Treating Acute Alcoholic Liver Injury by Natural Polyphenols |
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liaorong1, wangjie1, shiliangen1, xuzongpu2, yangmingying2
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1.College of Animal Sciences, Zhejiang University;2.浙江大学动物科学学院
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| Abstract: |
| Acute alcoholic liver injury resulting from the large quantity and high frequency of alcohol intake over a short time seriously harms patients’ health, and has increased significantly in recent years. Extracted from plants, natural polyphenols possess effective anti-inflammatory and anti-oxidation properties, and show higher drug-like feature due to their unique chemical structures. Currently, dozens of natural polyphenols have been identified with therapeutic effects for acute alcoholic liver injury, and exploring the relevant mechanisms will undoubtedly provide important reference for their depth development as well as new drug design. In this review, we firstly introduce the pathogenesis of acute alcoholic liver injury, and then summarize the mechanisms of treating acute alcoholic liver injury by natural polyphenols based on their structure and function, and finally we propose the research focus for future development of natural polyphenols. |
| Key words: acute alcoholic liver injury natural polyphenols treating mechanisms |
