灵芝酸结构、药理作用及机制研究进展

Research progress on structure, pharmacological action and mechanism of Ganoderma acid

关键词:  灵芝酸  结构  抗炎  抗肿瘤  药理作用  分子机制

Key words:  ganoderic acid  structure  anti-inflammatory  anti-tumor  pharmacological effect  molecular mechanism

摘要:

灵芝作为我国知名真菌类中药，具有补气安神，止咳平喘的功效。灵芝酸是灵芝的主要活性成分之一，具有抗炎、抗肿瘤、抗衰老、保护神经系统和心肌细胞、改善脏器损伤及调节糖脂代谢等多种药理作用，在治疗炎症、癌症、神经系统相关疾病等方面均具有良好的效果。该综述通过对灵芝酸的结构和药理作用进行综述，阐明灵芝酸药理作用机制，为灵芝酸的临床应用和新药开发提供参考。

Abstract:

Ganoderma lucidum, as a well-known Chinese fungal traditional Chinese medicine, has the effect of invigorating qi and calming nerves, relieving cough and relieving asthma. Ganoderic acid is one of the main active components of Ganoderma lucidum. It has many pharmacological effects, such as anti-inflammation, anti-tumor, anti-aging, protection of nervous system and cardiomyocytes, improvement of organ damage, regulation of glucose and lipid metabolism, etc. It has good effects in the treatment of inflammation, cancer and nervous system-related diseases. In this paper, the structure and pharmacological action of ganoderic acid were reviewed, and the pharmacological mechanism of ganoderic acid was elucidated, so as to provide reference for its clinical application and new drug development.