玉竹化学成分和药理作用的研究进展及其质量标志物的预测分析

Research progress on chemical composition and pharmacological effects of Polygonatum odoratum and prediction analysis of its quality markers

关键词:  玉竹  质量标志物  高异黄酮  n-香豆酰酪胺  多糖

Key words:  Polygonatum odoratum (Mill.) Druce  Quality markers  homoisoflavonoids  N-p-trans-Coumaroyltyramine  Polysaccharide[1]

摘要:

玉竹为百合科植物玉竹Polygonatum odoratum(Mill.)Druce干燥根茎，是我国传统中药材之一。研究表明玉竹成分复杂，含有甾体皂苷类、多糖类、黄酮类、生物碱类、挥发油类等成分，具有降血糖、降血脂、抗疲劳、抗老化等活性。通过对玉竹的化学成分和药理作用进行综述，并基于质量标志物(quality marker,Q-Marker)理论，从植物亲缘性及特有性，有效性、可测性、复方配伍和网络药理学等方面预测玉竹的Q-Marker，初步预测3-O-β-d-吡喃葡萄糖基-(1-2)-[β-d-吡喃木糖基-(1-3)]-β-d-吡喃葡萄糖基-(1-4)-吡喃半乳糖基-25(S)-spirost-5(6)-en-3β,14alpho-diol_qt、4',5,7-三羟基-6-甲基-8-甲氧基-羟基黄酮、4',5,7-三羟基-6,8-二甲基-高异氟烷酮、多糖苷E_qt、4',5,7-三羟基-6-甲基羟基黄酮、4'-甲氧基-5,7-二羟基-6,8-二甲基-高异氟烷酮、n-香豆酰酪胺、(Z)-3-(4-hydroxy-3-甲氧基-phenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide等可作为玉竹的主要Q-Marker，为玉竹的质量评价提供科学依据。

Abstract:

Polygonatum odoratum(Mill.)Druce is one of the traditional Chinese medicinal materials.Studies have shown that the composition of Polygonatum odoratum is complex,including steroidal saponins,polysaccharides,flavonoids,alkaloids,volatile oils and other components,with hypoglycemic,hypolipidemic,anti-fatigue,anti-aging and other activities.The chemical constituents and pharmacological effects of Polygonatum odoratum were reviewed.Based on thetheory of quality marker(Q-Marker),the Q-Marker of Polygonatum odoratum was predicted from the aspects of plant affinity and specificity,effectiveness.measurability,compound compatibility and network pharmacology.It is preliminarily predicted that 3-O-β-d-glucopyranosyl-(1-2)-[β-d-xylopyranosyl-(1-3)]-β-d-glucopyranosyl-(1-4)-galactopyranosyl-25(S)-spirost-5(6)-en-3β,14alpho-diol_qt, 4',5,7-trihydroxy-6-methyl-8-methoxy-hydroxyflavone, 4',5,7-trihydroxy-6,8-dimethyl-homoisofluranone,polyglycoside E_qt, 4',5,7-trihydroxy-6-methyl-hydroxyflavone, 4'-methoxy-5,7-dihydroxy-6,8-dimethyl-homoisofluranone,n-coumaroyltyramine, (Z)-3-(4-hydroxy-3-methoxy-phenyl)-N-[2-(4-hydroxyphenyl)ethyl]acrylamide can be used as the main Q-Marker of Polygonatum odoratum, which provides a scientific basis for the quality evaluation of Polygonatum odoratum.