基于微生物-肠-脑轴中医治疗偏头痛的研究进展

Research progress of Traditional Chinese medicine treatment of migraine based on Microbial-intestinal-brain axis

关键词:  偏头痛  微生物-肠-脑轴  中医治疗  综述

Key words:  Migraine  Microbial-intestinal-brain axis  Chinese medicine treatment  Summarize

摘要:

偏头痛(migraine)是一种慢性神经血管性疾病,其发病机制尚不明确,目前比较认可的有三叉神经血管学说、皮质扩散抑制学说等。脑肠轴是肠道微生物参与大脑与肠道双向信息交流的通路,可影响偏头痛的发作。偏头痛在祖国医学中属于“脑风”“头痛”的范畴,中医治疗偏头痛安全有效,副作用小。近几年,越来越多研究提示偏头痛与微生物-肠-脑轴有一定联系,中药、针刺、艾灸等可以通过影响脑肠肽水平、肠道菌群多样性和丰度等干预偏头痛发病机制以达到镇痛效果。因此,脑肠肽、肠道菌群的改变可能为中医治疗偏头痛的潜在机制。文章结合最新研究成果,基于微生物-脑肠轴理论综述偏头痛的发病机制及中医学对偏头痛患者微生物-肠-脑轴通路的影响,为科学研究偏头痛及临床诊治提供参考。

Abstract:

Migraine is a chronic neurovascular disease,and its pathogenesis is still unclear.At present,trigeminal neurovascular theory and cortical spreading depression are relatively recognized.Brain-gut axis is a pathway for intestinal microorganisms to participate in two-way information exchange between brain and intestine,which can affect the attack of migraine.Migraine belongs to the category of "Brain wind" and "Headache" in tradational Chinese medicine,which is safe and effective in treating migraine with little side effects.In recent years,more and more studies have suggested that migraine has a certain relationship with microbial-intestinal-brain axis.Traditional Chinese medicine,acupuncture and moxibustion can interfere with the pathogenesis of migraine by affecting the level of brain-intestine peptide and the diversity and abundance of intestinal flora to achieve analgesic effect.Therefore,the changes of brain-gut peptide and intestinal flora may be the potential mechanism of traditional Chinese medicine in treating migraine.Based on the latest research results,this paper based on the theory of microbial-brain axis,summarizes the pathogenesis of migraine and the influence of traditional Chinese medicine on the microbial-intestinal-brain axis pathway of migraine patients,so as to provide reference for scientific research and clinical diagnosis and treatment of migraine.