基于电子舌技术的儿童用药羧甲司坦口服溶液口感评价研究

Study on taste evaluation of oral solution of carboxmesteine for children based on electronic tongue technology

关键词:  儿童用药  电子舌  适口性评价

Key words:  Pediatric medication  electronic tongue  palatability evaluation

摘要:

目的：对临床常用的羧甲司坦口服溶液开展体外适口性评价，为儿科临床用药提供参考依据。方法：选取儿科临床常用的5款羧甲司坦口服溶液，采用电子舌技术开展不同厂家羧甲司坦口服溶液苦味评价，通过对电子舌测定的响应值进行雷达图、主成分分析及计算欧氏距离确定口感适宜的品种。结果：羧甲司坦口服溶液经服用后的苦味回味较低，其苦味主要是先味所导致；主成分分析中两个PC的累计贡献率达到98.3%，表明电子舌能够较好地反映原始数据的绝大部分信息，但不同厂家口服液的电势值差异不大，通过与原料药口感对比分析，揭盲发现北京诚济制药股份有限公司生产的羧甲司坦口服溶液（贝灵）无糖型（规格：100ml:2g）与原料药的欧氏距离最长（5.63）。结论：本研究发现羧甲司坦口服溶液（贝灵）无糖型（规格：100ml:2g）具有较好的口感，为临床用药选择提供口感参考依据，有助于提高临床患儿的服药依从性。

Abstract:

OBJECTIVE In vitro palatability evaluation of oral carboxymesteine solutions commonly used in clinical practice was carried out to provide a reference basis for pediatric clinical use. METHODS Five oral carboxymesteine solutions commonly used in pediatric clinics were selected, and the bitter taste evaluation of oral carboxymesteine solutions from different manufacturers was carried out by using the electronic tongue technique, and the suitable varieties for taste were identified by radar charts, principal component analysis, and calculation of Euclidian distance of the response values determined by the electronic tongue. RESULTS The results showed that the bitter aftertaste of carboxymethylsteine oral solution was relatively low, and the bitter taste was mainly caused by the first taste. In the principal component analysis, the cumulative contribution rate of the two PCs reached 98.3%, indicating that the electronic tongue can better reflect most of the information of the original data. Through comparison and analysis with the taste of the API, it was found that the sugar-free version of carboxymethylsteine oral solution (Beiling) produced by Beijing Chengji Pharmaceutical Co., Ltd. had the longest Euclide distance (5.63) from the API. CONCLUSION In this study, we found that carboxymethylsteine oral solution (Beiling) Sugar-free type (specification: 100ml:2g) has a better taste, which provides a taste reference basis for clinical drug selection and helps to improve the drug adherence of children in the clinic.