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引用本文:魏钊汝,陆学超.百令片治疗结缔组织病相关间质性肺病的临床疗效观察[J].中国现代应用药学,2024,41(23):55-61.
weizhaoru,luxuechao.Clinical Efficacy of Bailing Tablet in Treating Interstitial Lung Disease Associated with Connective Tissue Disease[J].Chin J Mod Appl Pharm(中国现代应用药学),2024,41(23):55-61.
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百令片治疗结缔组织病相关间质性肺病的临床疗效观察
魏钊汝1,2, 陆学超1
1.青岛大学附属青岛市海慈医院(青岛市中医医院);2.山东中医药大学第一临床医学院
摘要:
摘要:目的 观察百令片治疗结缔组织病相关间质性肺病(Connective tissue disease-related interstitial lung disease,CTD-ILD)的疗效及对患者细胞因子及T-淋巴细胞亚群的影响,探讨百令片治疗CTD-ILD的疗效和可能作用机制。方法:将80例CTD-ILD患者随机分为对照组、治疗组各40例。对照组患者予西医常规治疗,治疗组在此基础上加百令片口服,疗程3个月。主要观察指标为中医证候积分、ACQ评分、总体疗效评分、六分钟步行距离(6MWD)及T淋巴细胞亚群(CD4+%、CD8+%、CD4+/CD8+T细胞比值)、细胞因子(IL-4、IL-10、IFN-γ、TNF-α)水平。结果:治疗后,治疗组ACQ评分、中医证候积分比对照组有明显下降(P<0.05),总体有效率及六分钟步行距离显著高于对照组(P<0.05)。治疗组患者CD4+%、CD8+%及IL-4、TNF-α明显比对照组下降(P<0.05),CD4+/CD8+T细胞比值、IFN-γ、IL-10水平均较治疗前增高,且IFN-γ、IL-10较对照组显著增高(P<0.05)。治疗前、后两组患者诸安全性指标均未见明显异常,无不良事件。结论:百令片辅助治疗CTD-ILD患者疗效确切,可显著改善临床症状,有助于患者心肺功能的恢复,能够调节T-淋巴细胞亚群及相关细胞因子,减轻炎症反应,抑制肺纤维化进展。
关键词:  结缔组织病相关间质性肺病  百令片  冬虫夏草  T-淋巴细胞亚群  细胞因子
DOI:
分类号:
基金项目:山东省中医药科技项目;青岛市2018-2019 年度中医药科研项目;
Clinical Efficacy of Bailing Tablet in Treating Interstitial Lung Disease Associated with Connective Tissue Disease
weizhaoru,luxuechao
Qingdao Haici Hospital Affiliated to Qingdao University (Qingdao Hospital of Traditional Chinese Medicine)
Abstract:
ABSTRACT: OBJECTIVE To explore the treatment effect of Bailing tablet on patients with Connective tissue disease associated interstitial lung disease(CTD-ILD)and its effects on cytokines and T-lymphocyte subsets of patients, and to research the therapeutic effect and possible mechanism of Bailing tablet in the treatment of CTD-ILD.METHODS 80 cases of CTD-ILD patients were divided randomly into control and treatment group. Patients in control group (n=40) were treated with regular treatment ,and on the basis of the control group,patients in treatment group (n=40) were treated with Bailing tablets for 3 months. The main outcome measures were the traditional Chinese medicine(TCM)syndrome score, ACQ score, overall efficacy ,6-minute walking distance (6MWD),T-lymphocyte subsets (CD4+%,CD8+%,CD4+/CD8+T cell ratio),and cytokines (IL-4、IL-10,IFN-γ,TNF-α).RESULTS After treatment, the ACQ and TCM score in treatment group were lower than those in control group (P<0.05),the overall efficacy and 6MWD in treatment group were higher than those in control group (P<0.05).CD4+%, CD8+%, IL-4,and TNF-α in treatment group were lower than control group (P<0.05), the ratio of CD4+/CD8+ and the levels of IFN-γ and IL-10 were higher than those before treatment, IFN-γ and IL-10 were significantly increased compared with control group (P<0.05).There were no significant abnormalities in safety indexes and no adverse events before and after the treatment. CONCLUSION Bailing tablet is effective in the adjuvant treatment of CTD-ILD patients, which can significantly improve clinical symptoms, contribute to the recovery of patients' cardiopulmonary function, regulate T-lymphocyte subpopulation and related cytokines, reduce inflammatory response, and inhibit the progression of pulmonary fibrosis.
Key words:  connective tissue disease-related interstitial lung disease  bailing tablet  cordyceps sinensis  t-lymphocyte subsets  cytokines
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