JAK抑制剂在儿童疾病中的研究进展

Research Progress of JAK Inhibitors in Childhood Diseases

关键词:  JAK抑制剂  儿童疾病  研究进展

Key words:  JAK inhibitor  Childhood diseases  Research progress

摘要:

本文深入探讨了Janus激酶-信号转导子和转录激活因子（JAK-STAT）途径在多种儿童疾病中的核心调控作用，并展望了JAK抑制剂在这些疾病治疗中的潜力。JAK-STAT途径作为细胞信号传导的关键机制，对细胞的增殖、分化及功能调控至关重要。当其异常激活时，会诱发一系列免疫性疾病。在多种成人疾病治疗中，JAK抑制剂已显示显著疗效，为儿童疾病治疗提供了新思路。本文检索近年来国内外相关文献，介绍了JAK抑制剂在多种儿童免疫性疾病和血液系统疾病中中的研究进展，为JAK抑制剂进一步开发与应用提供参考。

Abstract:

This paper explores the central regulatory role of the Janus kinase-signal transductor and transcriptional activator (JAK-STAT) pathway in a variety of childhood diseases, and looks forward to the potential of JAK inhibitors in the treatment of these diseases. As a key mechanism of cell signaling, JAK-STAT pathway is crucial for cell proliferation, differentiation and functional regulation. When it is abnormally activated, it can induce a series of immune diseases. In the treatment of a variety of adult diseases, JAK inhibitors have shown significant efficacy, providing a new idea for the treatment of childhood diseases. In this paper, we reviewed the relevant literature at home and abroad in recent years, and introduced the research progress of JAK inhibitors in a variety of children immune diseases and hematological diseases, so as to provide reference for the further development and application of JAK inhibitors.