| 引用本文: | 张爱花,张颖,雷璇,靳雅珂,高蓉,宋逍,马爱华.网络药理学结合特征图谱及多元统计分析预测热炎宁合剂质量标志物[J].中国现代应用药学,2025,42(24):131-141. |
| ZHANG Ai-hua,ZHANG Ying,LEI Xuan,JIN Ya-ke,GAO Rong,SONG Xiao,MA Ai-hua.Q-markers Pediction Analysis of Reyanning Mixture Based on Network Pharmacology Combined with Aracteristic Chromatogram and Multivariate Statistical Analysis[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(24):131-141. |
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| 网络药理学结合特征图谱及多元统计分析预测热炎宁合剂质量标志物 |
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张爱花1,2,1, 张颖2, 雷璇2, 靳雅珂2, 高蓉2, 宋逍2, 马爱华1
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1.陕西省药品监督管理局;2.陕西中医药大学
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| 摘要: |
| 摘 要 目的 基于网络药理学及特征图谱预测热炎宁合剂抗甲流的质量标志物。方法 基于文献及网络药理学筛选出热炎宁合剂关键药效成分，结合热炎宁合剂HPLC特征图谱，预测热炎宁合剂的质量标志物，并进行分子对接验证和含量测定。结果 热炎宁合剂的质量标志物为咖啡酸、虎杖苷、大黄素和白藜芦醇，它们能与主要抗甲流靶点稳定结合，其含量在多批次样品间具有一定差异，其中虎杖苷含量相对较高。结论 咖啡酸、虎杖苷、大黄素和白藜芦醇可作为热炎宁合剂抗甲流的质量标志物。 |
| 关键词: 热炎宁合剂 质量标志物 网络药理学 特征图谱 甲型流感 |
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| 基金项目:国家重点研发计划(2019YFC1711204)；陕西省教育厅项目(21JC011) |
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| Q-markers Pediction Analysis of Reyanning Mixture Based on Network Pharmacology Combined with Aracteristic Chromatogram and Multivariate Statistical Analysis |
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ZHANG Ai-hua1,2,1, ZHANG Ying2, LEI Xuan2, JIN Ya-ke2, GAO Rong2, SONG Xiao2, MA Ai-hua1
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1.Shaanxi Medical Products Administration;2.Shaanxi University of Chinese Medicine
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| Abstract: |
| ABSTRACT OBJECTIVE To predict the quality markers(Q-markers) of Reyanning Mixture for anti-A influenza based on fingerprint and network pharmacology. METHODS The key pharmacodynamic components of Reyanning mixture were screened based on literature and network pharmacology. These components combined with HPLC fingerprint of Reyanning mixture to predicte the Q-markers of Reyanning mixture. And the molecular docking verification and content determination were carried out. RESULTS The Q-markers of Reyanning mixture were caffeic acid, polydatin, emodin and resveratrol. They bind stably to major anti-A influenza targets. There was some difference in its content among batches of samples. The content of polydatin was higher relatively. CONCLUSION The caffeic acid, polydatin, emodin and resveratrol can be used as Q-markers of Reyanning mixture anti-A influenza. |
| Key words: Reyanning Mixture quality markers network pharmacology fingerprints influenza A virus |
