| 引用本文: | 鲍梦依,赵家靖,严晨毓,冯尚,潘纲,李海峰,王跃明,姚林,舒强.儿童多动症数字药物的神经机制、应用进展与临床挑战[J].中国现代应用药学,2025,42(22):50-58. |
| Bao Mengyi,Zhao Jiajing,Yan Chenyu,Feng Shang,Pan Gang,Li Haifeng,Wang Yueming,Yao Lin,Shu Qiang.The Neural Mechanism, Application Progress and Clinical Challenges of Digital Therapeutics for ADHD Children[J].Chin J Mod Appl Pharm(中国现代应用药学),2025,42(22):50-58. |
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| 儿童多动症数字药物的神经机制、应用进展与临床挑战 |
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鲍梦依,赵家靖,严晨毓,冯尚,潘纲,李海峰,王跃明,姚林,舒强
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1.浙江大学医学院附属儿童医院;2.浙江大学计算机科学与技术学院;3.上海数药智能科技创新中心;4.南湖脑机交叉研究院;5.浙江大学脑与脑机融合前沿科学中心;6.浙江大学脑机智能全国重点实验室;7.国家儿童健康与疾病临床医学研究中心
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| 摘要: |
| 注意缺陷多动障碍（Attention-Deficit/Hyperactivity Disorder, ADHD）的传统药物治疗面临副作用显著、依从性差及社会接受度不高等困境。为应对这些挑战，数字疗法（Digital Therapeutics, DTx）作为一种安全、高效、个体化的非药物干预新范式应运而生。本综述聚焦于ADHD的DTx，首先从神经机制角度揭示其可能的作用原理；其次，系统评述了包括游戏化认知训练、行为监测和反馈系统、沉浸式交互技术和人工智能驱动的个性化干预在内的主要技术路径及其临床应用证据；最后，客观比较了DTx与传统药物在疗效、安全性及经济性等方面的差异，并探讨了其在应用中的挑战与前景，以期为构建药物与DTx相结合的综合治疗体系提供新思路。 |
| 关键词: 注意缺陷多动障碍 数字疗法 认知训练 虚拟现实 可穿戴设备 人工智能 |
| DOI： |
| 分类号:R729 |
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| The Neural Mechanism, Application Progress and Clinical Challenges of Digital Therapeutics for ADHD Children |
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Bao Mengyi1, Zhao Jiajing2, Yan Chenyu1, Feng Shang3, Pan Gang4, Li Haifeng1, Wang Yueming5, Yao Lin6, Shu Qiang7,8
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1.Children’s Hospital, Zhejiang University School of Medicine;2.The College of Computer Science and Technology, Zhejiang University;3.Shanghai SDO Digital Therapeutics Innovation Center;4.The Nanhu Brain-computer Interface Institute;5.MOE Frontiers Science Center for Brain and Brain-Machine Integration, Zhejiang University;6.The State Key Laboratory of Brain-Machine Intelligence, Zhejiang University;7.National Clinical Research Center for Childrens Health &8.Diseases
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| Abstract: |
| Traditional pharmacological treatments for Attention-Deficit/Hyperactivity Disorder (ADHD) face challenges such as significant side effects, poor adherence, and low social acceptance. To address these issues, Digital Therapeutics (DTx) have emerged as a safe, effective, and personalized non-pharmacological intervention paradigm. This review focuses on the application of DTx in ADHD management. It first explores the potential neural mechanisms underlying DTx interventions, followed by a systematic overview of key technological pathways—such as gamified cognitive training, behavioral monitoring and feedback systems, immersive interaction technologies, and AI-driven personalized interventions—and their supporting clinical evidence. Finally, it compares DTx with traditional medications in terms of efficacy, safety, and cost-effectiveness, and discusses current challenges and future prospects. This work aims to provide new insights into developing integrated treatment frameworks that combine pharmacotherapy with digital interventions for ADHD. |
| Key words: attention deficit hyperactivity disorder digital therapeutics cognitive training virtual reality wearable devices artificial intelligence |
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