| 引用本文: | 丁娜娜,郝闻致,张瀛仁,南楠,李琳,邹坦,孙艳茹,李爱心,李晓娟,陈家旭.小胶质细胞功能障碍与抑郁症的研究进展[J].中国现代应用药学,2026,43(13):165-174. |
| dingnana,haowenzhi,zhangyingren,nannan,lilin,zoutan,sunyanru,liaixin,lixiaojuan,chenjiaxu.Research progress on microglia dysfunction and depression[J].Chin J Mod Appl Pharm(中国现代应用药学),2026,43(13):165-174. |
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| 小胶质细胞功能障碍与抑郁症的研究进展 |
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丁娜娜1, 郝闻致1, 张瀛仁1, 南楠2, 李琳2, 邹坦1, 孙艳茹2, 李爱心2, 李晓娟1, 陈家旭1
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1.暨南大学;2.北京中医药大学
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| 摘要: |
| 小胶质细胞作为中枢系统中主要的的胶质细胞，其数量、形态及密度的变化与单胺类神经递质、神经突触传递、炎症反应等相互调节，在抑郁症发病中发挥显著作用。研究发现，小胶质细胞可通过调节单胺类神经递质、神经突触可塑性、神经炎症等参与抑郁症的发生发展。而中医药则通过调节小胶质细胞极化的表型，协调抑郁症相关的发病途径，降低炎症因子的表达水平，实现抗抑郁的目的。本文基于此进行综述，以期为抑郁症非神经元病理机制研究提供新的思路，为抗抑郁药物的研发提供参考。 |
| 关键词: 小胶质细胞 抑郁症 中医药 神经炎症 |
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| 基金项目:(82074331)；国家自然科学(82074331)； |
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| Research progress on microglia dysfunction and depression |
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dingnana1, haowenzhi1, zhangyingren1, nannan2, lilin2, zoutan1, sunyanru2, liaixin2, lixiaojuan1, chenjiaxu1
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1.Jinan University;2.Beijing University of Traditional Chinese Medicine
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| Abstract: |
| As the main glial cells in the central nervous system, microglia play a significant role in the pathogenesis of depression through changes in their number, morphology and density, which are mutually regulated by monoamine neurotransmitters, synaptic transmission, and inflammatory response. Studies have found that microglia can participate in the occurrence and development of depression by regulating monoamine neurotransmitters, synaptic plasticity, and neuroinflammation. Traditional Chinese medicine achieves the purpose of anti-depression by regulating the phenotype of microglial polarization, coordinating the pathogenesis pathways related to depression, and reducing the expression level of inflammatory factors. Based on this, this article reviews the research in order to provide new ideas for the study of non-neuronal pathological mechanisms of depression and provide a reference for the development of antidepressant drugs. |
| Key words: microglia depression traditional Chinese medicine neuroinflammation |
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