传承雪域藏医药经典名方精华,创新驱动民族药现代化高质量发展[1]

Preserving the Essence of Classic Tibetan Medical Formulas from the Highlands: Driving High-Quality, Innovation-Driven Modernization of Ethnic Medicine

关键词:  藏药  资源调查  经典名方  物质基础  药理机制  高质量发展

Key words:  Tibetan medicine  resource survey  classic formulas  chemical basis  pharmacological mechanisms  high-quality development

摘要:

藏医药是中华医药宝库的重要组成部分,也是雪域高原各族人民群众在长期生产生活实践中形成的宝贵健康财富。然而受现有技术限制,藏药现代化研究仍面临物质基础不清、药效机制不明、质量标准缺失等关键瓶颈。本期《中国现代应用药学》藏药专栏汇聚多篇论文,从藏药资源调查与可持续利用、藏医药理论与文献整理、藏药药效物质基础与药理机制三个维度,系统呈现了藏药现代化研究的最新进展。专栏融合谱效关系、网络药理学、分子对接、多模型药效评价等前沿技术手段,聚焦肝损伤、肝癌、肺损伤、胃溃疡、骨关节炎等高海拔常见重大疾病,深入阐释藏药活性成分调控NLRP3炎症小体/细胞焦亡、RAGE-PI3K-Akt、NF-κB等多通路协同治疗的科学内涵。专栏研究成果为推动藏医药传承创新与民族药高质量发展提供了重要的学术引领与科学支撑。

Abstract:

ABSTRACT: Tibetan medicine is an integral part of the treasure trove of Chinese medicine and a valuable health legacy formed by the people of all ethnic groups on the Tibetan Plateau through long-term production and daily life practices. However, due to limitations in existing technology, research on the modernization of Tibetan medicine still faces critical bottlenecks, such as an unclear material basis, unknown mechanisms of action, and a lack of quality standards. This issue of “Chinese Journal of Modern Applied Pharmacy” features a special section on Tibetan medicine, bringing together multiple papers that systematically present the latest advances in research on the modernization of Tibetan medicine from three dimensions: the survey and sustainable use of Tibetan medicinal resources, the systematization of Tibetan medicine theory and literature, and the active ingredient basis and pharmacological mechanisms of Tibetan medicines. The special issue integrates cutting-edge technical approaches-including structure-activity relationships, network pharmacology, molecular docking, and multi-model pharmacological evaluation-to focus on major diseases common at high altitudes, such as liver injury, liver cancer, lung injury, gastric ulcers, and osteoarthritis. It provides an in-depth explanation of the scientific principles underlying the synergistic treatment of these conditions through the regulation of multiple pathways-including the NLRP3 inflammasome/pyroptosis, RAGE-PI3K-Akt, and NF-κB pathways-by active components in Tibetan medicine. The research findings presented in this special issue provide important academic guidance and scientific support for promoting the inheritance and innovation of Tibetan medicine and the high-quality development of ethnic medicine.