| 引用本文: | 梁爱红,沈小卜,李素云,李美香,刘慧晴,黄兰娥,陈熙,雷小灿.白藜芦醇保护配子发生的作用及机制研究进展[J].中国现代应用药学,2021,38(22):2906-2912. |
| LIANG Aihong,SHEN Xiaobu,LI Suyun,LI Meixiang,LIU Huiqing,HUANG Lan'e,CHEN Xi,LEI Xiaocan.Research Progress on the Protective Effect and Mechanism of Resveratrol on Gametogenesis[J].Chin J Mod Appl Pharm(中国现代应用药学),2021,38(22):2906-2912. |
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| 白藜芦醇保护配子发生的作用及机制研究进展 |
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梁爱红1, 沈小卜2, 李素云1, 李美香1, 刘慧晴1, 黄兰娥1, 陈熙1, 雷小灿1
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1.南华大学, 衡阳医学院应用解剖与生殖医学研究所, 湖南 衡阳 421001;2.湖南省南华大学与岳阳妇幼保健院医学研究生创新培养基地, 湖南 岳阳 416000
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| 摘要: |
| 白藜芦醇是一种天然的非黄酮类多酚化合物，具有抗炎、抗氧化、抗凋亡、保护心血管等多种药理学作用，对机体的多种疾病都具有积极的治疗作用。本研究着重总结了白藜芦醇在物理化学因素、代谢异常等不良因素下对卵泡发生、卵母细胞和胚胎发育以及精子发生过程中所发挥的保护作用。同时通过综述白藜芦醇调控下丘脑-垂体-性腺轴、氧化应激、PI3K/Akt等信号通路及表观遗传学修饰等方面的相关机制，为白藜芦醇应用于改善临床因卵泡发育和精子发生障碍诱发不孕不育提供理论参考。 |
| 关键词: 白藜芦醇 卵泡发育 精子发生 作用 机制 |
| DOI：10.13748/j.cnki.issn1007-7693.2021.22.026 |
| 分类号:R966 |
| 基金项目:国家自然科学基金项目（81860733）；岳阳妇幼保健院横向科研项目（19yyfyhx001）；湖南省自然科学基金青年项目（2020JJ5500）；湖南省研究生科研创新项目（CX20210959） |
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| Research Progress on the Protective Effect and Mechanism of Resveratrol on Gametogenesis |
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LIANG Aihong1, SHEN Xiaobu2, LI Suyun1, LI Meixiang1, LIU Huiqing1, HUANG Lan'e1, CHEN Xi1, LEI Xiaocan1
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1.Clinical Anatomy & Reproductive Medicine Application Institute, University of South China, Hengyang, 421001, China;2.Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Yueyang 416000, China
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| Abstract: |
| Resveratrol is a natural non-flavonoid polyphenolic compound, which has lots of pharmacological effects, including anti-inflammatory, antioxidant, anti-apoptosis, cardiovascular protection and et al, which has positive therapeutic effects on various diseases of the body. In this study, the protective effects of resveratrol on folliculogenesis, oocyte and embryo development and spermatogenesis under adverse factors such as physicochemical factor and metabolic disturbance were summarized. At the same time, this paper reviews the relevant mechanisms of resveratrol regulating the hypothalamus-pituitaries-gonadal axis, oxidative stress, PI3K/Akt et al. Signaling pathways and epigenetic modification, so as to provide theoretical reference for the application of resveratrol in improving clinical infertility caused by follicular development and spermatogenesis disorders. |
| Key words: resveratrol follicle development spermatogenesis function mechanism |
