| 摘要: |
| 目的 研究硝酸异康唑新的合成工艺。方法 以三氯苯乙酮为起始原料经过还原、N-烷基化，成醚和精制四步合成硝酸异康唑。结果 总收率达到47.1%。结论 该反应原料易得，反应简单可行，该工艺为硝酸异康唑的工业化生产提供了依据。 |
| 关键词: 硝酸异康唑 新工艺 三氯苯乙酮 |
| DOI： |
| 分类号: |
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| Novel Synthesis Technology of Isoconazole |
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JI Shichun, LI Qin
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Nanjing Hailing R&D for Chinese Traditional Medicina Pharmaceutical Technology Co. Ltd., Nanjing 210094, China
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| Abstract: |
| OBJECTIVE To study the new synthesis technology of isocinazole. METHODS The new technology is begin with 2,2',4'-trichloroacetophenone and after reduction, N-alkylation, etherification and crystallization four-step to synthesis isoconazole. RESULTS The total yield of the reaction reached 47.1%. CONCLUTION The raw materials are easy to obtain and the reactions are simple. This technology provides the rule for industrialization and makes a contribution for the antifungal medicine industry. |
| Key words: isocanozole synthesis 2,2',4'-trichloroacetophenone |
