| 引用本文: | 王士群,朱宇珍,郑学宝.Chou-Talalay在抗肿瘤联合用药中的研究应用概况[J].中国现代应用药学,2013,30(4):449-453. |
| WANG Shiqun,ZHU Yuzhen,ZHENG Xuebao.Study and Application of Chou-Talalay Method for Anti-tumor Drug Combination[J].Chin J Mod Appl Pharm(中国现代应用药学),2013,30(4):449-453. |
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| 摘要: |
| 联合用药已经广泛地运用于多种疾病的治疗过程中，如抗菌、抗病毒、抗肿瘤等治疗领域。然而，目前为止国内外学者关于联合用药后疗效的评价标准仍没有达成一致，尤其是药物协同作用的评价。Chou-Talalay是目前被广泛认可的药物协同作用定量分析方法。本文针对抗肿瘤研究领域，对该法的研究应用概况作一综述，为合理用药的研究提供线索和参考。 |
| 关键词: Chou-Talalay 抗肿瘤 联合用药 定量分析 |
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| Study and Application of Chou-Talalay Method for Anti-tumor Drug Combination |
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WANG Shiqun1,2, ZHU Yuzhen1, ZHENG Xuebao2
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1.Department of Pharmacology, Guangdong Medical College, Zhanjiang 524023, China;2.Guangdong Key Laboratory for Research and Development of Natural Drugs, Guangdong Medical College, Zhanjiang 524023, China
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| Abstract: |
| Drug combination has been widely used in the therapeutic process of many serious illness, such as anti-bacterial, anti-viral and anti-tumor therapeutic, etc. However, so far the domestic and overseas scholars about evaluation standards of the curative effects have not arrived at any agreement yet, especially the synergistic effect of drug combination. Chou-Talalay method is now generally accepted as synergy quantitative analysis method for drug combination. Aiming at the anti-tumor research field, we comprehensively reviewed the method to lay a good basis for the rational use of drugs. |
| Key words: Chou-Talalay method anti-tumor drug combination quantitative analysis |
