| 引用本文: | 杨建科,郑鹛,金海明,罗书平.HIV蛋白酶抑制剂的关键中间体——手性氨基环氧烷合成研究进展[J].中国现代应用药学,2014,31(4):510-516. |
| YANG Jianke,ZHENG Mei,JIN Haiming,LUO Shuping.Research Progress of Chiral Amino Epoxide-The Important Intermediate of HIV Protease Inhibitors[J].Chin J Mod Appl Pharm(中国现代应用药学),2014,31(4):510-516. |
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| 摘要: |
| 拟肽类HIV蛋白酶抑制剂是临床治疗艾滋病的主要药物，它们的共性结构片段——(2R, 3S)-3-氨基-4-苯基-2-丁醇从关键中间体手性氨基环氧烷得到，笔者对该中间体的合成研究进行归纳和总结。 |
| 关键词: HIV蛋白酶抑制剂 手性氨基环氧烷 合成 |
| DOI： |
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| 基金项目:浙江省重点创新团队项目(2011R09002-01) |
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| Research Progress of Chiral Amino Epoxide-The Important Intermediate of HIV Protease Inhibitors |
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YANG Jianke1, ZHENG Mei1, JIN Haiming2, LUO Shuping2
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1.Hangzhou Huadong Medicine Group Research Academy Co Ltd., Hangzhou 310012, China;2.State Key Laboratory Breeding Base of Green Chemistry–Synthesis Technology, Zhejiang University of Technology, Hangzhou 310014, China
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| Abstract: |
| Peptide analogue HIV protease inhibitors are the main drugs for clinical treatment of AIDS. They have a common structural segment (2R, 3S)-3-amino-4-phenyl-2-butanol, which is synthesized by chiral amino epoxide. In this review, the recent research process in the synthesis methods of this key intermediate is summarized. |
| Key words: HIV protease inhibitors chiral amino epoxide synthesis methods |
