pH敏感型纳米递药系统在肿瘤靶向治疗中的作用

Applications of pH Sensitive Nanoparticle Drug Delivery System for Antitumor Targeting Therapy

关键词:  pH敏感性  纳米递药系统  肿瘤靶向治疗

Key words:  pH sensitive  nanoparticle drug delivery system  antitumor targeting therapy

摘要:

目的 综述目前pH敏感纳米递药系统用于肿瘤靶向治疗中的国内外研究进展。方法 在Pubmed和Google上检索近年国内外资料，阐明pH敏感纳米递药系统靶向肿瘤治疗的作用机制，对超顺磁性纳米粒、胶束、树状大分子等相关研究成果进行总结和评价。结果 近年来研发的pH响应的纳米载体可通过EPR效应积聚于肿瘤组织，并在弱酸性的肿瘤细胞外液或经内吞作用后在细胞质或溶酶体中释放药物。该pH敏感型载体能促进药物的靶向递送，在减少系统性不良反应的同时提高肿瘤化疗疗效。结论 pH敏感纳米递药系统在肿瘤靶向治疗中具有广阔的应用前景，开发具有靶向性、高效性、安全性的递药系统是目前该领域研究主要方向之一。

Abstract:

OBJECTIVE To review the current domestic and international research progress of pH sensitive nanoparticle drug delivery system for antitumor targeting therapy. METHODS Searching the relevant information both at home and abroad in recent years in the Pubmed and Google, elucidating the mechanism of pH sensitive nanoparticle delivery system for antitumor therapy, such as superparamanetic iron oxide nanoparticles, micelles, dendrimers and so on. RESULTS pH responsive nanocarriers could accumulate in tumor tissue through the EPR effect and release drug in weak acidic tumor extracellular fluid or by endocytosis in the cytoplasm or lysosomal. These systems could promote the targeted delivery of drugs, while reducing systemic side effects and improving the efficacy of chemotherapy. CONCLUSION The development of pH sensitive nanoparticle drug delivery system with targeting, high efficiency and safety has broad application prospects in antitumor therapy and become one of the main research directions in the field.