| 引用本文: | 于莲,崔丹,应晓英,杜永忠.表面修饰脂质纳米粒给药系统的研究进展[J].中国现代应用药学,2011,28(2):108-112. |
| YU Lian,CUI Dan,YING Xiaoying,DU Yongzhong.Research Progress in Drug Delivery of Surface Modified Lipid Nanoparticles[J].Chin J Mod Appl Pharm(中国现代应用药学),2011,28(2):108-112. |
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| 摘要: |
| 脂质纳米粒是一种极具潜力的新型药物传输载体，对脂质纳米粒表面修饰是近年来的研究热点。通过表面修饰的手段能有效的避免单核巨噬细胞的吞噬、延长脂质纳米粒在体内的循环时间、主动靶向于病灶部位。本文就脂质纳米粒的体内命运及脂质纳米粒表面修饰的研究进展做一综述。 |
| 关键词: 脂质纳米粒 表面修饰 单核吞噬细胞系统 主动靶向 研究进展 |
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| 基金项目:浙江省医药卫生科学研究基金计划(2009A054) |
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| Research Progress in Drug Delivery of Surface Modified Lipid Nanoparticles |
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YU Lian1, CUI Dan1, YING Xiaoying2, DU Yongzhong2
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1.College of Pharmacy, Jiamusi University, Heilongjiang Province Key Laboratory of Biological Medicine Formulation, Jiamusi 154007, China;2.College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
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| Abstract: |
| Lipid nanoparticles have attracted increasing attention as potential drug carrier. The researches relating to surface modification of lipid nanoparticles become a hot spot during recent years. Through surface modification, the lipid nanoparticles could effectively decrease the phagocytosis by mononuclear phagocyte, prolong retention time in circulation, and achieve the active targeting to action site of drug. This review focused on in vivo fate of lipid nanoparticles and the developments of surface modification. |
| Key words: lipid nanoparticles surface modification mononuclear phagocyte active targeting research progress |
