银杏叶提取物对慢性阻塞性肺疾病急性加重期患者血管内皮功能的影响

Effect of Ginkgo Biloba Leaf Extract on Function of Vascular Endothelial Cell of Patients with Chronic Obstructive Pulmonary Disease in Acute Exacerbation Stage

关键词:  银杏叶提取物  慢性阻塞性肺疾病  急性加重期  内皮细胞

Key words:  Ginkgo biloba leaf extract  chronic obstructive pulmonary disease  acute exacerbation stage  endothelial cell

摘要:

目的 探讨银杏叶提取物对慢性阻塞性肺疾病急性加重期(AECOPD)患者血管内皮功能的影响。方法 将60例AECOPD患者随机分为常规治疗组(CT组)，银杏叶组(GBLE组)，每组30例；并选择同期30例健康体检者作为对照组。两组常规治疗相同，GBLE组每日加用舒血宁注射液20 mL静脉滴注，连用2周。酶联免疫吸附法检测血清一氧化氮(NO)、血栓调节蛋白(TM)和血管假血友病因子(vWF)。结果 两个治疗组治疗前NO，TM显著低于对照组(P<0.01)，vWF显著高于对照组(P<0.01)。治疗后，两组NO，TM水平较治疗前显著升高(P<0.01)，而GBLE组升高更为显著，与CT组比较有统计学差异(P<0.01)；两组vWF水平较治疗前显著下降(P<0.01)，GBLE组下降较CT组更为显著(P<0.01)。结论 银杏叶提取物有显著改善AECOPD患者血管内皮细胞功能的作用，可预防血栓性疾病。

Abstract:

OBJECTIVE To investigate the influence of Ginkgo biloba leaf extract (GBLE) on the function of vascular endothelial cell of patients with chronic obstructive pulmonary disease in acute exacerbation stage(AECOPD). METHODS Sixty patients with AECOPD were randomly divided into two groups: conventional treatment (CT) group and GBLE treatment (GBLE) group, each group consisted of 30 cases, and 30 healthy adults served as control group. All AECOPD patients were given conventional treatment, while for the patients in GBLE group, 20 mL GBLE were given through intravenous drip everyday in addition for 2 weeks. The levels of the serum nitric oxide(NO), thrombomodulin (TM) and von Willebrand factor (vWF) in the blood samples were determined with enzyme linked immunosorbent assay (ELISA). RESULTS The level of NO and TM were decreased significantly in AECOPD patients compared with control group before treatment(P<0.01). And the level of vWF was elevated significantly in AECOPD patients compared with control group before treatment(P<0.01). After intervention, the level of NO and TM in both treatment groups were significantly elevated(P<0.01), and the elevation in GBLE group was more prominent than CT group(P<0.01). The level of vWF in both treatment groups was significantly decreased(P<0.01), and the decrease in GBLE group was more prominent than CT group(P<0.01). CONCLUSION GBLE has the effect on improving endothelial function in patients with AECOPD, the medicine may be used to prevent thrombotic diseases.